Library: LA498NS: Natural Sciences Capstone: M1 &amp; M2: Ethics Essay

Ethical Theories Resources

Your Ethics Essay will be developed around a particular topic concerning the CRISPR Cas9® and the associated Gene Driver technology. Your focus will be on the ethical issues that are specific to the application of the technology in your topic.

Ethics essay topic areas-selected resources

CRISPR Therapeutics and Vertex Announce New Clinical Data for Investigational Gene-Editing Therapy CTX001™ in Severe Hemoglobinopathies
CRISPR Therapeutics. (2020, June 12). CRISPR Therapeutics and Vertex announce new clinical data for investigational gene-editing therapy CTX001™ in severe hemoglobinopathies at the 25th Annual European Hematology Association (EHA) Congress [Press release]. https://crisprtx.gcs-web.com/news-releases/news-release-details/crispr-therapeutics-and-vertex-announce-new-clinical-data
Designer Genes
Jacbosen, R. (2017). Designer genes. Mother Jones, 42(5), 44-48.
Gene Editing Tried in Embryos
Le Page, M. (2017). Gene editing tried in embryos. New Scientist, 233(3117), 8. https://doi.org/10.1016/S0262-4079(17)30500-6
Human Genome Editing: Our Future Belongs to All of Us
Baylis, F. (2019). Human genome editing: Our future belongs to all of us. Issues in Science & Technology, 35(3), 42–44.

CRISPR-Directed Microbiome Manipulation Across the Food Supply Chain
Barrangou, R., & Notebaart, R. A. (2019). CRISPR-directed microbiome manipulation across the food supply chain. Trends in Microbiology, 27(6), 489–496. https://doi.org/10.1016/j.tim.2019.03.006
Fields of Dreams
Cohen, J. (2019). Fields of dreams. Science, 365(6452), 422–425. https://doi.org/10.1126/science.365.6452.422
Gene Editing for Good
Gates, B. (2018). Gene editing for good. Foreign Affairs, 97(3), 166–170.
Message Control
Borel, B. (2017). Message control. Scientific American, 317(4), 68-70.
Regulating Gene-Edited Crops: Advocates of Second-Generation Genetically Modified Crops are Making Choices Likely to Trigger Another Round of Public Opposition
Kuzma, J. (2018). Regulating gene-edited crops: Advocates of second-generation genetically modified crops are making choices likely to trigger another round of public opposition. Issues in Science & Technology, 35(1), 80–85.
Risk and Safety Considerations of Genome Edited Crops: Expert Opinion
Lassoued, R., Macall, D. M., Smyth, S. J., Phillips, P. W. B., & Hesseln, H. (2019). Risk and safety considerations of genome edited crops: Expert opinion. Current Research in Biotechnology, 1,11–21. https://doi.org/10.1016/j.crbiot.2019.08.001

Building a Trojan Pig
Hayasaki, E. (2019). Building a Trojan pig. Wired, 27(4), 58-61.
CRISPR in Livestock: From Editing to Printing
Menchaca, A., dos Santos-Neto, P. C., Mulet, A. P., & Crispo, M. (2020). CRISPR in livestock: From editing to printing. Theriogenology, 150, 247–254. https://doi.org/10.1016/j.theriogenology.2020.01.063
Gene Doping—In Animals? Ethical Issues at the Intersection of Animal Use, Gene Editing, and Sports Ethics
Neuhaus, C. P., & Parent, B. (2019). Gene doping—in animals? Ethical issues at the intersection of animal use, gene editing, and sports ethics. Cambridge Quarterly of Healthcare Ethics, 28(1), 26-39.
Is CRISPR an Ethical Game Changer?
Schultz-Bergin, M. (2018). Is CRISPR an ethical game changer? Journal of Agricultural & Environmental Ethics, 31(2), 219-238.
Precise CRISPR/Cas9 Editing of the NHE1 Gene Renders Chickens Resistant to the J Subgroup of Avian Leukosis Virus
Koslová, A., Trefil, P., Mucksová, J., Reinišová, M., Plachý, J., Kalina, J., Kučerová, D., Geryk, J., Krchlíková, V., Lejčková, B., & Hejnar, J. (2020). Precise CRISPR/Cas9 editing of the NHE1 gene renders chickens resistant to the J subgroup of avian leukosis virus. Proceedings of the National Academy of Sciences of the United States of America, 117(4), 2108–2112. https://doi.org/10.1073/pnas.1913827117
Prioritizing the Protection of Welfare in Gene-edited Livestock
Shriver, A. (2020). Prioritizing the protection of welfare in gene-edited livestock. Animal Frontiers, 10(1), 39-44.
Sheep and Goat Genome Engineering: From Random Transgenesis to the CRISPR Era
Kalds, P., Zhou, S., Cai, B., Liu, J., Wang, Y., Petersen, B., Sonstegard, T., Wang, X., & Chen, Y. (2019). Sheep and goat genome engineering: From random transgenesis to the CRISPR era. Frontiers in Genetics, 10,1-27. https://doi.org/10.3389/fgene.2019.00750
Super-Muscly Pigs: Trading Ethics for Efficiency
Benz-Schwarzburg, J., & Ferrari, A. (2016). Super-muscly pigs: Trading ethics for efficiency. Issues in Science and Technology, 32(3), 29-32.

Debugging the Planet
Mechanic, M. (2017). Debugging the planet. Mother Jones, 42(5), 49.
Deleting a Species
Jacobsen, R. (2018). Deleting a species. Pacific Standard, 11(4), 48–57.
Gene Editing for Good
Gates, B. (2018). Gene editing for good. Foreign Affairs, 97(3), 166–170.

Who are the People in your Neighborhood? Personas Populating Unregulated mHealth Research
Doerr, M., Guerrini, C., Rothstein, M. A., & Wilbanks, J. T. (2020). Who are the people in your neighborhood? Personas populating unregulated mHealth research. Journal of Law, Medicine & Ethics, 48, 37–48. https://doi.org/10.1177/1073110520917028
My Body, My Genes
Pearlman, A. (2017). My body, my genes. New Scientist, 236(3152), 22-23. https://doi.org/10.1016/S0262-4079(17)32257-1
How Should Physicians Respond When They Learn Patients are Using Unapproved Gene Editing Interventions?
Riley Chapman, C., & Caplan, A. L. (2019). How should physicians respond when they learn patients are using unapproved gene editing interventions? AMA Journal of Ethics, 21(12), 1021-1028.
The Rogue Experimenters
Talbot, M. (2020). The rogue experimenters. New Yorker, 96(14), 40-49.
Regulating Genetic Biohacking
Zettler, P. J., Guerrini, C. J., & Sherkow, J. S. (2019). Regulating genetic biohacking. Science, 365(6448), 34–36. https://doi.org/10.1126/science.aax3248

CRISPR-Baby Scientist Fails to Satisfy his Critics
Cyranoski, D. (2018). CRISPR-baby scientist fails to satisfy his critics. Nature, 564(7734), 13-14. http://dx.doi.org/10.1038/d41586-018-07573-w
Ethical Issues Related to Research on Genome Editing in Human Embryos.
Niemiec, E., & Howard, H. C. (2020). Ethical issues related to research on genome editing in human embryos. Computational and Structural Biotechnology Journal, 18, 887–896. https://doi.org/10.1016/j.csbj.2020.03.014
The First Genetically Gene‐Edited Babies: It's “Irresponsible and Too Early"
Ma, Y., Zhang, L., & Qin, C. (2019). The first genetically gene‐edited babies: It's “irresponsible and too early”. Animal Models and Experimental Medicine, 2(1), 1-4. http://dx.doi.org/10.1002/ame2.12052

CRISPR Critters and CRISPR Cracks
Charo, R. A., & Greely, H. T. (2015). CRISPR critters and CRISPR cracks. American Journal of Bioethics, 15(12), 11–17. https://doi.org/10.1080/15265161.2015.1104138
DNA Revolution
Specter, M. (2016). DNA revolution. National Geographic, 230, 31-41,44,46,48-49,52-55.
Gene Drives
Olson, J. B. (2017). Gene drives. The National Academies in Focus, 16, 20-22.
The Life Editor
Le Page, M. (2015). The life editor. New Scientist, 228(3050), 32–37.